Studies on the Common Active Site of Growth Hormone REVISION OF THE AMINO ACID SEQUENCE OF AN ACTIVE FRAGMENT OF BOVINE GROWTH HORMONE* (Received for publication, August 12, 1974)
نویسنده
چکیده
A fragment, A-II, isolated from a component of a tryptic digest of bovine growth hormone has growth-promoting activity in rats and metabolic activity in humans similar to human growth hormone. The amino acid sequence of this peptide has been reinvestigated and revised. The 38-amino acid peptide was cleaved with cyanogen bromide, chymotrypsin, and trypsin. The amino acid sequences were then established by Edman degradation as well as with overlapping peptides. Homology in the sequence was good between this bovine growth hormone fragment and peptides occurring in ovine growth hormone, human growth hormone, and human chorionic somatomammotropin.
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